Association of bacteria with hydrocephalus in Ugandan infants.

نویسندگان

  • Lingling Li
  • Abinash Padhi
  • Sylvia L Ranjeva
  • Sarah C Donaldson
  • Benjamin C Warf
  • John Mugamba
  • Derek Johnson
  • Zephania Opio
  • Bhushan Jayarao
  • Vivek Kapur
  • Mary Poss
  • Steven J Schiff
چکیده

OBJECT Infantile hydrocephalus in East Africa is predominantly postinfectious. The microbial origins remain elusive, since most patients present with postinfectious hydrocephalus after antecedent neonatal sepsis (NS) has resolved. METHODS To characterize this syndrome in Ugandan infants, the authors used polymerase chain reaction targeting bacterial 16S ribosomal DNA from CSF to determine if bacterial residua from recent infections were detectable. Bacteria were identified based on the relationship of genetic sequences obtained with reference bacteria in public databases. The authors evaluated samples from patients presenting during dry and rainy seasons and performed environmental sampling in the villages of patients. RESULTS Bacterial DNA was recovered from 94% of patients. Gram-negative bacteria in the phylum Proteobacteria were the most commonly detected. Within this phylum, Gammaproteobacteria dominated in patients presenting after infections during the rainy season, and Betaproteobacteria was most common following infections during the dry season. Acinetobacter species were identified in the majority of patients admitted after rainy season infection. CONCLUSIONS Postinfectious hydrocephalus in Ugandan infants appears associated with predominantly enteric gram-negative bacteria. These findings highlight the need for linking these cases with antecedent NS to develop more effective treatment and prevention strategies.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparing the Efficiency of Two Treatment Methods of Hydrocephalus: Shunt Implantation and Endoscopic Third Ventriculostomy

Introduction: Hydrocephalus is one of the most common diseases in children, and its treatment requires brain operation. However, the pathophysiology of the disease is very complicated and still unknown.  Methods: Endoscopic Third Ventriculostomy (ETV) and Ventriculoperitoneal Shunt (VPS) implantation are among the common treatments of hydrocephalus. In this study, Cerebrospinal Fluid (CSF) hyd...

متن کامل

Systematic ventriculographic studies in infants born with meningomyelocele and encephalocele. The incidence and development of hydrocephalus.

Increasing experience and the introduction of new techniques in the treatment of congenital hydrocephalus demand its earliest possible recognition and knowledge of its natural history. By far the commonest type of congenital hydrocephalus is the one associated with a meningomyelocele or encephalocele. The presence of hydrocephalus in such infants should be suspected at birth, simply because the...

متن کامل

Survival of Ugandan infants with subtype A and D HIV-1 infection (HIVNET 012).

Virologic factors may influence survival of HIV-1-infected infants. We compared survival of Ugandan infants with subtype A and subtype D HIV-1 infection. This study was performed in the context of the Ugandan clinical trial HIVNET 012, which compared the efficacy of single-dose nevirapine (NVP) and short-course zidovudine (AZT) for prevention of HIV-1 mother-to-child transmission. HIV-1 subtype...

متن کامل

Multidrug Resistance in Infants and Children

Bacterial infections may cause disease and death. Infants and children are often subject to bacterial infections. Antimicrobials kill bacteria protecting the infected patients andreducing the risk of morbidity and mortality caused by bacteria. The antibiotics may lose their antibacterial activity when they become resistant to a bacteria. The resistance to different antibiotics in a bacteria is ...

متن کامل

The impact of irrigation on different methods of breast milk in mothers of low birth weight infants, in ICU unit of Imam Reza Hospital

Introduction: Breast milk health is one of the most salient elements in feeding of premature infants. Generally in initial of breast feeding, different methods of disinfecting such as irrigation with usual detergents like water and soap are used to eliminate the probable bacteria.  The necessity  of  the  usage  of  such  items  has  not  been  mentioned  in  some  studies, and  even at the tim...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of neurosurgery. Pediatrics

دوره 7 1  شماره 

صفحات  -

تاریخ انتشار 2011